Lipstick Cliqa follows an all-female vampire Chola gang that finds themselves forced into a turf battle where their only option is to defend their neighborhood and avenge their family's honor, resulting in a trail of blood. They are a fierce, all-female gang of shape-shifting vampire cholas, led by the fearless Morissa who expertly wields her trademark razor whip. After Morissas's grandmother is killed by a rival gang called the Stitches, Morissa and her Lipstick Cliqa crew vow revenge.